Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c56a2217367f9d8a66da0da1ce030123 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_27e1ea5f65e8f958e48f1a9d53fdbb45 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8257 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8258 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-82 |
filingDate |
2013-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2016-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c71e61aa6690810633e27df1a22420d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bb2835b4cedb075f0cfee08734089395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d9a3959ffc660964eb3007b8eb79ce6b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0fbb4d65ddf87692127c280414feb9af http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a06119a2a3559f6ba2aaa5f87183295f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_adf345de3dee5fdcc7a85be2a9a4e866 |
publicationDate |
2016-11-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-9506079-B2 |
titleOfInvention |
DNA replicon system for high-level rapid production of vaccines and monoclonal antibody therapeutics in plants |
abstract |
Plant viral vectors have great potential in rapid production of proteins, but no simple Here a geminivirus-based system for high-yield and rapid production of oligomeric protein complexes, including virus-like particle (VLP) vaccines and monoclonal antibodies (mAbs) is described. In particular, a single vector that contains two non-competing replicons for transient expression in Nicotiana benthamiana leaves is described. The correct assembly of these subunit proteins into functional oligomeric structures (VLPs or full-size mAb) is also described. This system advances plant transient expression technology by eliminating the need for non-competing viruses, and thus, enhances the realistic commercial application of this technology for producing multiple-subunit protein complexes. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021198693-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11130956-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11697819-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019194680-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11058766-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11078491-B2 |
priorityDate |
2008-08-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |