| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_64565acdcc52331729793a894d422711
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fc733dd6753a78e608aff0a6d6aafc44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d1593acf0951b660bbbbef1a538c00ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7246b60d92985665f6fd2100a6499eba
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed1c00e98c24be30429fc74c9146f03c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b01dc986eb117dbdc8efdc26d5b48812
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c1d92350e9c0fe38d74d42778d869b9a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e869ff27b7f8e75c7a412a2a8b9d81b3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-495
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-496 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-496 |
| filingDate |
2005-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8eb3e643db81c4fcc67ccd872b9b431e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_96d61c0e899ceafcd1cc994461cd661e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af5787c9345bd5260f6316d13e6ef361
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_55c3729bcfd20e59b830f3cf70d57b64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_530ed34b91a7778f26b76eb0a3494252
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f44f92320d34017cdc708a490fd8871d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d8e392f8e6a1f7ca2b3a87bcef83254d |
| publicationDate |
2016-11-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9492446-B2 |
| titleOfInvention |
Manufacturing method of solid dispersion containing itraconazole |
| abstract |
The present invention relates to a method for preparing an itraconazole-containing solid dispersion. The itraconazole-containing solid dispersion according to the preparing method of the present invention has both improved solubility and rapid dissolution rate so that it has an excellent bioavailability. The itraconazole-containing solid dispersion of the present invention is also independent of pH variation of human stomach so that it can minimize the absorption variation of intra- and inter-individuals. In addition, the itraconazole-containing solid dispersion according to the preparing method of the present invention is stable for a long time. The present invention also provides an economical and environment-friendly method for manufacturing an itraconazole-containing composition because the method adds a lactic acid in a solution comprising itraconazole to decrease the amount of an organic solvent needed to dissolve itraconazole. |
| priorityDate |
2004-06-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |