| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3ac4560afea7c312447ea9a2547d6149
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7fe989d354816244a92a4e8a07220198
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1721d75f5bf603447ec5a26b5c1c0be0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_36551c8d08ce624a57ba65202923ac26 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-542 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-542 |
| filingDate |
2012-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fceea6d8ccfa34b9cb1606946a8dba3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_80452e861c24d421ec6f667d29aeeba6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4e7d34b9ea301d68d06ee1742c4c143 |
| publicationDate |
2016-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9470680-B2 |
| titleOfInvention |
Fluorescence-based approach to monitor release factor-catalyzed termination of protein synthesis |
| abstract |
Provided are probes comprising a class 1 release factor conjugated to a fluorescent label and methods of making the probes. Also provided are methods for detecting conformational changes in ribosomes and associated molecules, such as class 1 release factors. In addition, methods of identifying a compound for reducing nonsense-mediated decay of mRNA and/or for inhibiting termination of protein synthesis at a premature stop codon, are described. Methods of assaying RF3 activity are also included. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11016026-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11105812-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11435358-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11162952-B2 |
| priorityDate |
2011-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |