http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9447067-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0d9661ae4e8a56ade56ae3e53cbff395 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9dd824ddad33648c66984647bd72e120 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C213-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D319-08 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D319-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C213-00 |
| filingDate | 2015-05-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4be5b7e899975ee93f47c53ab7300504 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_559bcd1d49740b1fee5dd60c8beb1929 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4518b6f405535f4ec41d74f486f0f19 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1b84452242c8cae08638f5a7a97260a9 |
| publicationDate | 2016-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9447067-B2 |
| titleOfInvention | Method of preparing intermediate of salmeterol |
| abstract | A method of preparing an intermediate of salmeterol (Compound 1, 2-amino-1-(2,2-dimethyl-4H-1,3-benzodioxin-6-yl)ethanol) includes: reacting compound 2 with 2-methoxypropene in a first organic solvent to produce a reaction solution including compound 3, compound 2 including a 2-bromo precursor of Compound 1; reacting compound 3 with a nitrogen source to produce compound 4; reacting compound 4 with sodium borohydride in a second organic solvent to produce compound 5; and debenzylating compound 5 by ammonium formate/palladium-carbon catalytic transfer hydrogenation in a third organic solvent to produce Compound 1. A method of preparing salmeterol includes preparing Compound 1, and reacting Compound 1 to prepare salmeterol. |
| priorityDate | 2014-10-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 118.