http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9446145-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5c50b17bd6ac893a28bee6b4bb8ead88 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0980cfc4886967a8d8c2fe45d330bf01 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_416fc7aef3c14505693a2da3887d1582 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48384 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6865 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6849 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6803 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48561 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48623 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2010-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_37e4e6ecf5e7516bfa8e09fd8a6aef61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_349a15ef5438e89b5e77a79a4ac5d8bc |
| publicationDate | 2016-09-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9446145-B2 |
| titleOfInvention | Curcumin-antibody conjugates as anti-cancer agents |
| abstract | The invention relates to curcumin derivatives having the formula I: wherein: Z represents: H 3 CO A represents —CH 2 —CH 2 — or —CH═CH—; L represents —C(O)—(NH) n1 —R—(NH) n2 —C(O)—; R represents a saturated or unsaturated, branched or unbranched hydrocarbyl chain having a minimum of 3 carbon atoms in the chain; wherein the maximum number of carbon atoms in the chain is 24; and wherein the carbon atoms of the chain can be replaced by at least one heteroatom, wherein the heteroatoms are independently —O— or —NH 2 —, with the proviso that each heteroatom is separated from each other heteroatom by at least two carbon atoms; n1 and n2 independently represent 0 or 1; and Y represents an antibody that binds specifically to a target antigen of a tumor cell. The invention further relates to methods of method of inhibiting the growth of tumors in a human by administering an effective amount of the curcumin derivative, and to methods of producing the curcumin derivative. |
| priorityDate | 2009-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 213.