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filingDate 2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_34af724a23c742956780a5b25b9bf25b
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publicationDate 2016-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9422527-B2
titleOfInvention Drug target site within gp120 of HIV
abstract The present invention relates to a method of designing an inhibitor of the binding of HIV (human immunodeficiency virus) glycoprotein (gp)120 to a CD4-receptor or to the integrin alpha4 beta7 (a4b7). The inhibitor interacts with at least two amino acid residues comprised in six motifs within the 3-dimensional structure of gp120. Also provided are compounds, pharmaceutical compositions thereof and uses thereof in the development of an inhibitor of the binding of a HIV gp120 to a CD4-receptor or an integrin alpha4 beta7 (a4b7). The inhibitors are useful for the prevention or treatment of an HIV infection and/or diseases associated with an HIV infection.
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