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filingDate 2011-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_543237e0fb7cf042df8d7c4779db95c5
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publicationDate 2016-08-02-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9404107-B2
titleOfInvention Integration of genes into the chromosome of Saccharopolyspora spinosa
abstract This invention includes a process for the identification and validation of a neutral polynucleotide integration site within the S. spinosa genome. In addition, the invention includes the use of the neutral site and methods for the integration of a polynucleotide containing a gene expression cassette, which is stably maintained and expressed over subsequent generations. The invention includes neutral integration sites that can be disrupted without negatively impacting spinosyn production, growth or other desired metabolic characteristics.
priorityDate 2011-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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