http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9382525-B2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd656439ab15d45443c6dc65a2ca298f |
classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y305-03001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48215 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
filingDate | 2013-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2016-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_60dd8347c3bf8ba83195e7241ebb3eab http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9829be224ebf086a974631d3e4a4be61 |
publicationDate | 2016-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-9382525-B2 |
titleOfInvention | Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents |
abstract | The present invention provides a site-specific pegylated arginase conjugate and method for producing thereof. The site-specific pegylated arginase is homogeneous in molecular weight and shows therapeutic effect for treating cancers and viral infections. The method for producing the arginase conjugate comprises genetically modifying the gene encoding an arginase so that the PEG moiety can be attached to the enzyme at a predetermined, specific intended sites. This is achieved by removing the PEG-attaching amino acid residue(s) at undesirable site(s) while keeping or adding cysteine(s) at the desirable site(s) of the enzyme. Two exemplary embodiments of the pegylated arginase conjugate are directed to human arginase I (HAI) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys 45 of the enzyme and Bacillus caldovelox arginase (BCA) where a polyethylene glycol (PEG) moiety is site-specific covalently bonded to Cys 161 of the enzyme. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022195629-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11717562-B2 |
priorityDate | 2009-03-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1239.