| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1f0f4f285f46fd38fb5dacbf1cc1a5b7
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a43fc39f71b6813cce9419db34c80fe2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3cff1e5cd36699c561cd27214ac11807 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1694
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1611
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-1647
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-22
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-31 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-25
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-26
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-23
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-22 |
| filingDate |
2012-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_117469848af95697cdbad357af183220
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_45a5cb1648723131b17497f28f5a7b88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc44cd341c7e1917975a768085dc0233 |
| publicationDate |
2016-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9381159-B2 |
| titleOfInvention |
Microspheres for controlled- or sustained-release delivery of therapeutics |
| abstract |
A new microsphere formulation (composition) for controlled- or sustained-release delivery of therapeutic ingredient(s), mainly peptides and proteins not over 10K in molecular weight, comprises at least a therapeutic ingredient, a helping agent (such as PH sensitive agent whose solubility is a function of pH) and a biodegradable polymer. The therapeutic ingredient(s) and the helping agent are in the form of fine particles, less than 1O um in diameter, encapsulated in the polymer which forms the microsphere matrix. A method for preparing the composition comprises a step of in-situ precipitating the therapeutic ingredient(s) and the helping agent to the fine particles and successive steps for forming the microspheres. Such a microsphere formulation offers a well-controlled release profile for prolonged period and encapsulation efficiency over 95%. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019099329-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018144603-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4011386-A1 |
| priorityDate |
2011-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |