| abstract |
A compound represented by the general formula (C): n n(wherein R 101 represents a substituted or unsubstituted aromatic heterocyclic group,n R 102 , R 103 , R 104 and R 105 may be the same or different, and each represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 3 carbon atoms, or a haloalkyl group having 1 to 3 carbon atoms, and R 106 represents a hydrogen atom, or a saturated or unsaturated hydrocarbon group which is a straight or branched chain having 1 to 12 carbon atoms, but excluded is the case where R 101 is a 3-furyl group, R 102 , R 103 , R 104 and R 105 are all methyl groups, and R 106 is a methyl group, a 4-methyl-3-pentenyl group or a 4,8-dimethyl-3,7-nonadienyl group); or a pharmaceutically acceptable salt thereof has selective inhibitory activity on hypoxic cell growth in a broad range of the concentration and therefore is useful as an active ingredient of a medicament for cancer prevention or treatment. |