http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9365824-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ed5a3acc981910db774c67ab53884ee1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_52c0937f6f874192126078abec056cfc http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5cc7cde3723313629dc8216a92add867 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-91 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2501-90 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0647 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-0789 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-00 |
| filingDate | 2005-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f832724ae297a52b700afd1629e3f9b9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7d4c1dc458956ccb7fea37561e0fbc1 |
| publicationDate | 2016-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9365824-B2 |
| titleOfInvention | Method for expanding postembryonic stem and progenitor cells from umbilical cord blood and immunotherapeutic agent |
| abstract | Method for obtaining and expanding postembryonic hematopoietic stem cells from umbilical cord blood while avoiding unwanted differentiation. Initial cells from umbilical cord blood are proliferated and multiplied ex vivo in a stroma-free medium and in the presence of a regio-modified glycan or glycosaminoglycan. The regio-modified glycan or glycosaminoglycan, e.g. a heparin derivative, is N-desulfated, and N-reacetylated or N-reacylated, in essence, on C2 atoms. The heparin derivative advantageously comprises less than 5 percent of C3-O-sulfate, at least 60 percent C2-O-sulfate, and it is preferably added in a quantity of 15 to 50 mg/L to the medium in order to stop an unwanted differentiation. The stem cells generated in this manner can differentiate, after expansion, into myeloma cells and lymphatic cells, and they can be used as an immunotherapeutic agent against many diseases. |
| priorityDate | 2004-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 49.