Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4385f6bbc5f04af361d60070fc6c13d7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6d66046712c629a9adf5aa6a15308ff4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_287360c9e36b81fc27a447fe3248b35e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8fa6d9f460d1b415a7ed8554e3ecf896 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14305f93e17b14689a8f0895709ebe59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8adaddc602ad7cb7f9e2d550681bb36d http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3982d76f7076d6871f8d552792433b04 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-1015 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2525-101 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2563-125 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-133 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6818 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6806 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6874 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34 |
filingDate |
2011-06-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2016-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89f8026be89f65379a030844240278b7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0558a8ce0e50fd51fb19b3d8c0a3a576 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65e2c19454dbd437716f7f9630d79095 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3de485d1fb5d3c2e2424815e59d18acf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6a626ad6f4e34a1b26b1f0a74180c52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_645e3f0efe6ab0e6ccea39cc432b4f83 |
publicationDate |
2016-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-9353412-B2 |
titleOfInvention |
Conformational probes and methods for sequencing nucleic acids |
abstract |
This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template. The method can include the steps of contacting the nucleic acid template with a conformationally labeled polymerase and at least four different nucleotide species under conditions wherein the conformationally labeled polymerase catalyzes sequential addition of the nucleotide species to form a nucleic acid complement of the nucleic acid template, wherein the sequential addition of each different nucleotide species produces a conformational signal change from the conformationally labeled polymerase and wherein the rate or time duration for the conformational signal change is distinguishable for each different nucleotide species; detecting a series of changes in the signal from the conformationally labeled polymerase under the conditions; and determining the rates or time durations for the changes in the signal, thereby determining the sequence of nucleotides for the nucleic acid template. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10161003-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10655176-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11168364-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10584375-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10443098-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10415029-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9951385-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11447823-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11180749-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10246744-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954551-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10975424-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9932631-B1 |
priorityDate |
2010-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |