| abstract |
The invention provides compounds of the Formula (I), n n n n n n n n n n n n in which W is independently selected from W 1 , W 2 , W 3 , W 4 , W 5 , n n n n n n n n n n n n n n n n or W represents a pair of substituents independently selected from H, alkyl, aryl or amide in which the amide is optionally part of a linking chain, and the Z n —Z n′ bonds (n=4-17; n′=n+1) are optionally of any whole or partial bond order, n Y is Y 1 n n n n n n n n n n n n n n n n or Y represents a pair of substituents independently selected from H, C 1 -C 6 alkyl, Z 5 or Z 6 aryl, or Y is optionally a bridging structure that may comprise one or more C 1 -C 6 amide, C 1 -C 6 ether, or C 1 -C 6 ester groups, R—R 39 are independently selected from no substituent, a lone pair of electrons, H, halogen, C 5 -C 6 aryl, C 1 -C 12 alkyl, amine, C 1 -C 6 alkylamine, C 1 -C 6 amide, nitro, cyano, carboxyl, C 1 -C 6 ester, phosphane, thiol, C 1 -C 6 thioether, OR 40 , and suitable pairs of adjacent R groups (R—R 39 ) may optionally together form part of a C 5 or C 6 aryl ring, a Z 5 or Z 6 ring, R 40 is independently selected from H, C 1 -C 6 alkyl, Z 5 or Z 6 aryl, C 1 -C 6 ester, poly(—C 2 O—), amine, and C 1 -C 6 alkylamine, Z—Z 24 are independently selected from C, N, P, O, and S, and X − is a pharmaceutically acceptable anion, for the treatment of cancer. |