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filingDate 2006-04-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_233a8741554cc0c66c65086f425c04d8
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publicationDate 2016-05-10-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9335331-B2
titleOfInvention Multiplexed biomarkers for monitoring the Alzheimer's disease state of a subject
abstract The present invention relates to a method for diagnosing a subject's Alzheimer's disease state. The method involves providing a database containing information relating to protein expression levels associated and not associated with Alzheimer's disease. The database includes information relating to at least a majority of the following proteins: albumin, alpha-1-antitrypsin, apolipoprotin E, apolipoprotein J, complement component 3, contactin, fibrin beta, Ig heavy chain, Ig light chain, neuronal pentraxin receptor, plasminogen, proSAAS, retinol-binding protein, transthyretin, and vitamin D binding protein. Information relating to proteins found in one or more cerebrospinal fluid samples from a subject is also provided and a database is used to analyze the information from the subject to diagnose the subject's Alzheimer's disease state. Also disclosed is a computer readable medium and a system, both useful in carrying out the present invention.
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