| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7e1d859a849b1914105888e68e430351
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_15cc4b540001c45baa07c1cfbe4567a0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bf644d3a0a2ca45729fe2ee5d064cdf5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5b050b863f3ea9a93194cf8c0e04268a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_18d92c46f60af8af24e262b67381d7eb |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2563-143
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2563-149
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-537 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-686
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6858 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N-
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate |
2011-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9370bf719abef143dd5d6225b2333700
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_70543d0288506ac0c4d81ef014652694
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_624c38975d8277c6f41f267175dc302e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c1e82ad98803ed044f4234d27010f4 |
| publicationDate |
2016-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9328343-B2 |
| titleOfInvention |
Method and compositions for detection and enumeration of genetic variations |
| abstract |
Many areas of biomedical research depend on the analysis of uncommon variations in individual genes or transcripts. Here we describe a method that can quantify such variation at a scale and ease heretofore unattainable. Each DNA molecule in a collection of such molecules is converted into a single particle to which thousands of copies of DNA identical in sequence to the original are bound. This population of beads then corresponds to a one-to-one representation of the starting DNA molecules. Variation within the original population of DNA molecules can then be simply assessed by counting fluorescently-labeled particles via flow cytometry. Millions of individual DNA molecules can be assessed in this fashion with standard laboratory equipment. Moreover, specific variants can be isolated by flow sorting and employed for further experimentation. This approach can be used for the identification and quantification of rare mutations as well as to study variations in gene sequences or transcripts in specific populations or tissues. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11247209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11351543-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11351544-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11123735-B2 |
| priorityDate |
2003-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |