http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9315510-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_db56fd9dcc212e88fc3d94483d2ffbed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_715d8b9e0766f4c9e40369925f1a04f2 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_949678697e071d10490d07809a8d0888 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3203708b1cb35bcba5eb4f46bb4821e1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2148270485fc095c60824dafc346fe8e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c53818f30acd12ab392543f08f0e9800 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-26 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-409 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H15-26 |
| filingDate | 2009-09-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_732b67a16efa633754e7210a58d029bf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_170d6dfe0c7f2a4c1d4b9424350d9cf7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6a175f84c33feccfca664cae395fc270 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_296c240ce5e604ef40d85aa6aa1115ac http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_842bebd03828ec6a2fd932729cb7fb0f |
| publicationDate | 2016-04-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9315510-B2 |
| titleOfInvention | Method and application of unsymmetrically meso-substituted porphyrins and chlorins for PDT |
| abstract | Biologically active compounds are provided that can be used as photosensitizers for diagnostic and therapeutic applications, particularly for PDT of cancer, infections and other hyperproliferative diseases, fluorescence diagnosis and PDT treatment of a non-tumorous indication such as arthritis, inflammatory diseases, viral or bacterial infections, dermatological, ophthalmological or urological disorders as well as providing methods to obtain them in pharmaceutical quality. One embodiment consists of a method to synthesize a porphyrin with a defined arrangement of meso-substituents and then converting this porphyrin system to a chlorin system by dihydroxylation or reduction, and if more than one isomer is formed separate them by chromatography either on normal or reversed phase silica. In another embodiment the substituents on the porphyrin are selected to direct the reduction or dihydroxylation to the chlorin so that a certain isomer is selectively formed. Another embodiment is to provide amphiphilic compounds with a higher membrane affinity and increased PDT-efficacy. In another embodiment a method to reductively cleave the osmate(VI)ester avoiding the use of gaseous H 2 S is provided. In another embodiment substituents are identified that via their steric and/or electronic influence direct the dihydroxylation or reduction with diimine so that one isomer is favored. Another embodiment consists of formulate the desired isomer into a liposomal formulation to be injected avoiding undesirable effects like solubility problems or delayed pharmacokinetics of the tetrapyrrole systems. |
| priorityDate | 2008-09-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 233.