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filingDate 2015-04-21-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2016-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb25fd371d36152fa9c872c4938c0d41
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publicationDate 2016-03-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9295661-B2
titleOfInvention Methods for reducing inter-patient variability of levodopa plasma concentrations
abstract The present invention provides methods of reducing the inter-patient variability of levodopa plasma concentrations in a population of Parkinson's disease patients. The methods of the invention comprise pulmonary administration of levodopa at therapeutically effective concentrations such that the inter-patient variability of levodopa plasma concentrations at time periods ranging from about 10 minutes post inhalation to about 60 minutes or more post inhalation have less than a 50% coefficient variation. The methods of the invention are particularly useful for treatment of motor fluctuations which arise as a side effect of L-Dopa therapy.
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priorityDate 2012-10-22-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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