http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9279117-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_806704d13726e2185d8cfe053e082687 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_658df3b9d24eb5224b37aaf605741db6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_81034b3047e61f02fcdff2cd80affdce |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0368 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-203 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0331 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6416 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
| filingDate | 2012-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2016-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d1c90c22cc696ec75a6e066ce309c562 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b2775bbe115a6de8cbc8c233498ecd60 |
| publicationDate | 2016-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9279117-B2 |
| titleOfInvention | Transgenic mouse conditionally expressing MMP12 for studying myelopoiesis, immunity and tumorigenesis |
| abstract | A myeloid-specific c-fms-rtTA/(TetO) 7 -CMV-MMP12 bitransgenic mouse model was created. Induction of MMP12 abnormally elevated frequencies and numbers of common myeloid progenitor (CMP) and granulocyte/macrophage progenitor (GMP) populations, and decreased the frequency and number of the megakaryocyte/erythrocyte progenitor (MEP) population in bone marrow. CD11b + /Gr-1 + immature cell population increased in multiple organs. An immunosuppressive function on T cell proliferation and function by CD11b + /Gr-1 + immature cells was seen in vitro and in vivo from MMP 12 over-expression. MMP 12 stimulated (Lin − ) progenitor cells to differentiate into CD11b + /Gr-1 + immature cells showing immunosuppression on T cell proliferation and function in vitro. Regulatory T cells were increased. In the lung, concentration of interleukin (IL)-6 was increased, which activated oncogenic signal transducer and increased expression of Stat3 downstream genes in epithelial tumor progenitor cells. Spontaneous emphysema and lung adenocarcinoma sequentially developed after MMP12 over-expression. MMP12-induced myeloid cell autonomous defect led to abnormal myelopoiesis, immune suppression and lung adenocarcinoma. |
| priorityDate | 2011-01-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 562.