| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e093b80edd05029eba3edfb1421161a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8d0fc2b70675ee19bd5fc464f5ae9061 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57419 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0039
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-0052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 |
| filingDate |
2014-08-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65023d5682fd11a6633268797616ccd4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2db1775fbd0dc3fe5e1d75573b5676a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_09d70c3b1c63775dad0bd768ec131c36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_43e8f6cbb24795fd49034ea090719c3e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_948fd9f59403b5796be159a5f6ae2b29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_125aff8f67acbc51f8d9fc8ce0155d3f |
| publicationDate |
2016-02-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9248202-B2 |
| titleOfInvention |
Two-photon probe for detecting copper(II) ion and quantitative estimation of copper(II) ion in human tissue using the same |
| abstract |
The present disclosure relates to a two-photon probe for in-vivo imaging, having high selectivity for copper(II) ion, and a method for quantitatively estimating copper(II) on (Cu 2+ ) in vivo using the same. The two-photon probe according to the present disclosure can detect intracellular free copper(II) on for a long period of time with a penetration depth greater than 90 μm in living cells and tissues without the problems of mistargeting and photobleaching and can quantitatively estimate copper(II) on concentration in vivo using the ratio of blue emission intensity at 400-450 nm and red emission intensity at 550-650 nm. |
| priorityDate |
2014-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |