| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4ac1a3fd86a82a54a356600fc1fa2704
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a95714d50528ed71ea5363e76378e13
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9931b670dabc3c966d9436010250ceb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c58a362565a0616bcc3901fcbf9643de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc2b03342511abc88f60c63f2acd96d0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_25f19b0b6a9eada86c8155c8c6c46fd8 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K51-1075 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6876
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5023
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K51-10 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-713
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P25-00 |
| filingDate |
2013-07-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2016-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f2638723436213fa5e1e55195f44f477
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1a5579750549823a6e5da5e35c8216f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cf39806a9720dc82ae690060d53ae77
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5056c71084795e167c71d5234e8ce1cd |
| publicationDate |
2016-01-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9226935-B2 |
| titleOfInvention |
Methods for modulating the expression and aggregation of a CAG-expanded gene product in cells and methods for identifying agents useful for doing the same |
| abstract |
This invention provides a method for modulating the expression of a first gene in a cell wherein the first gene is one containing more than 36 CAG trinucleotide repeats and encoding a protein that form polyglutamine-mediated protein aggregation. Suppression of the first gene is achieved by reducing the expression of SPT4 gene or SUPT4H gene. It can also be achieved by inhibiting the formation of a Spt4/Spt5 complex or a Supt4h/Supt5h complex. Also provided is a method for identifying an agent useful for modulating the expression and aggregation of CAG-expanded gene product, or treating a polyglutamine disease such as Huntington's disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016152978-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9862947-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10760077-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10675293-B2 |
| priorityDate |
2010-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |