| abstract |
Compounds according to Formula I, Formula II, Formula III, Formula V, Formula VI, or to Formula VII, n nand pharmaceutical compositions of compounds that conform to Formula IV or Formula VIII:n n nwhere R 1 through R 33 are prescribed, selectively inhibit P. falciparum dihydroorotate dehydrogenase. Accordingly, a method for preventing and treating malaria attaches to such compounds, as well as to pharmaceutically acceptable salts, solvates, stereoisomers, tautomers, and prodrugs thereof. |