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filingDate 2013-03-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9200328-B1
titleOfInvention Methods and kits for diagnosing the prognosis of cancer patients
abstract The prognosis of a cancer patient can be determined by analyzing the modulation of expression of specified genes in the tumor tissue. Genes uniquely up-regulated in adult stem cells that can reconstitute the tissue of the tumor are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor is an indication of good prognosis. Genes uniquely up-regulated in fetal stem cells are analyzed for up-regulation in the patient's tumor. Up-regulation of a plurality of such genes in the tumor are an indication of a poor prognosis. Specific genes are disclosed, the modulation of which, in a patient's prostate cancer tumor, will serve as an indication of prognosis. Patients with a good prognosis are subjected to watchful waiting. Patients with a poor prognosis are aggressively treated. Kits are provided containing a set of affinity reagents that specifically detect expression of the various genes.
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