| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_076afb00173199f13e7cf520f3a9a15d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1ca1f307bf07990dcc1c62fbd466bdd5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_42e94091a4fc81b8d0237117707cc7ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a798690b8d8373209ce8b9c200f8ab35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aa95bdd4850d67a1e1199aae4184b9bb |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1136
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-123
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-126
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D277-42 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D277-42
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-113 |
| filingDate |
2011-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0ea4052c1e7fe7a6616c1a75652ff04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2670d60207708842a20efa1bb798e53e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_897b8dac651cb2a57fa4751a68c6de3a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_21573964208a5a269e231f131070f0d7 |
| publicationDate |
2015-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9169295-B2 |
| titleOfInvention |
Macrocycles and macrocycle stabilized peptides |
| abstract |
The invention provides methods of preparing macrocycles including macrocycle stabilized peptides (MSPs). Macrocycles and MSPs are prepared according to nucleophilic capture of an iminoquinomethide type intermediate generated from a suitably substituted 2-amino-thiazol-5-yl carbinol. The preferred nucleophile may be selected from an electron rich aromatic moiety in the case of macrocycles and, in the case of MSPs, at least one amino acid comprises an electron rich aromatic moiety. In addition, the concept can be extended to other related 5-membered heterocyclic systems in place of the thiazole, such as imidazole or oxazole. The conditions for the generation of the corresponding iminoquinomethide type intermediates may be similar or different than the conditions used for the 2-amino-thiazol-5-yl carbinol. |
| priorityDate |
2010-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |