abstract |
A method for production of hydroxycarboxylic acid amide compounds, including performing amide condensation between an α- or β-hydroxycarboxylic acid compound and an amine compound in the presence as a catalyst of an alkylboronic acid represented by R 3 B(OH) 2 (wherein R 3 is a primary alkyl group) or an arylboronic acid compound to produce a hydroxycarboxylic acid amide compound, the arylboronic acid compound being represented by Formula (1): n n n n n n n n n n n n (in Formula (1), —(CH 2 ) n NR 1 R 2 is bonded at an ortho position or a para position, n is 1 or 2, R 1 is a tertiary alkyl group, R 2 is a secondary or tertiary alkyl group, and —NR 1 R 2 may be a ring). |