| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2e3830f35387a1c32061dea3ee310851 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-5601
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-4828
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01R33-5605 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01V3-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01R33-56 |
| filingDate |
2014-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a439fb42f6115e0c72867abe482c40b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_33df0d9713a22bfb52e29eafd3a460ec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d476c860f919bd8a0e9aac2309f1de1b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_094677666b313a4b854cdfd532f7082e |
| publicationDate |
2015-10-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9157976-B2 |
| titleOfInvention |
CEST MRI methods for imaging glutaminolysis in cancer |
| abstract |
CEST imaging technique and MR scanning are used as an MRI method for measuring glutaminase mediated tumors. The method takes advantage of the fact that glutamine does not exhibit a significant Chemical Exchange Saturation Transfer (CEST) effect while glutamate does. In accordance with this method, one first obtains a glutamate CEST MRI map of the area of a tumor. L-glutamine (nontoxic up to several millimolar level) or glutaminase blocker is then injected and a post injection Glutamate CEST map is obtained. The difference in the spatial maps indicates the level of expression of glutaminase in the tumor. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10863918-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10156625-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10901058-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015042335-A1 |
| priorityDate |
2010-07-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |