| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_35bce0b8363dc3e87c11597734a15083 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-12 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-12 |
| filingDate |
2013-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7336ae501b6357f640547d8990bc1f48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2588fe5c79c2d4ea44cb44b0fa9487d5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_be6ef819eb75e15a1170150bd9dd83b4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_314d242f5533dd2bc924a877bc634bb1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc4a86bda5a04f438d96bda3f99bc2db |
| publicationDate |
2015-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9145406-B2 |
| titleOfInvention |
Process for preparing dasatinib monohydrate |
| abstract |
The present invention relates to an improved process for preparation of Dasatinib monohydrate Formula A, n ncomprising the steps of:n a) reacting the compound of Formula I with 1-(2-Hydroxyethyl)piperazine (Formula II) in the presence of acetonitrile solvent, an organic base and a phase transfer catalyst; nn n n n n n n n n n n n b) heating the reaction mixture at 50-80° C.; n c) adding water to the reaction mass obtained in step b); n d) cooling the reaction mixture to a temperature below 35° C.; n e) filtering and drying the material obtained in step d); n f) optionally purifying the product obtained from step e); n g) isolating the crystalline Dasatinib monohydrate. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11160805-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11007195-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10940149-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11052088-B2 |
| priorityDate |
2012-04-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |