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filingDate 2011-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2015-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e75ed802a0c5bcc6f7e47cfd4e1ada68
publicationDate 2015-09-08-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-9127255-B2
titleOfInvention 3-dimensional scaffolds for improved differentiation of pluripotent stem cells to hepatocytes
abstract The present invention relates to the use of 3-dimensional (3D) synthetic or animal-derived bioscaffolds as substrates for the improved growth and differentiation of hPS (Human pluripotent stem cells); these scaffolds being adapted for use in conjunction with existing cell culture lab plastic-ware. More specifically, it relates to the seeding of these scaffolds, either alone or in conjunction with various biologic matrix coatings, with hPS cells for the improved differentiation of said hPS cells into hepatocyte or hepatocyte-like cell types. The invention also relates to the seeding of partially-differentiated hepatocyte progenitors onto scaffolds for further differentiation into more mature hepatocyte-cell types.
isCitedBy http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10752879-B2
priorityDate 2010-06-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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