Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eaa62ee0f249275a25fc9193a5590db1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_30c79ea6efff966e0f2324215b93d25e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68c213ba9952360f439567152e047b18 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-056 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-206 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-052 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2217-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2267-0312 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2830-008 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-4711 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-71 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-1841 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0275 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-71 |
filingDate |
2009-05-26-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2015-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1dc5c1d540a754e22452176a7fafd809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bad76de017d2ffd4b1c35c55864dc776 |
publicationDate |
2015-08-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-9095126-B2 |
titleOfInvention |
Targeting TGF-β as a therapy for Alzheimer's disease |
abstract |
Described herein are compositions and methods for enhancing peripheral macrophage Aβ phagocytosis activity. The methods include inhibiting the TGF-β signaling pathway and activating the BMP signaling pathway in peripheral macrophages to promote central nervous system infiltration and enhance macrophage Aβ phagocytosis activity. Inhibition of TGF-β signaling and activation of BMP signaling in peripheral macrophages represents an advantageous anti-amyloid therapeutic approach for Alzheimer's disease. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11193129-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10570395-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10584337-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11198873-B2 |
priorityDate |
2008-05-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |