| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cac023d2e2874224ecbbcccbdea1fc91 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4709
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 |
| filingDate |
2012-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e78b4a8a861e50f8c878cceb1e24ad0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a41e636b9e5a070a527937924ab13e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b95d64254a7450c33b7da5a71b39110a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47aaa857f61ef9aa8c9e074dc4700074
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c0e4e17f83c79c6e2bb64b5310ae07f |
| publicationDate |
2015-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9090587-B2 |
| titleOfInvention |
7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-yl}-6-fluoro-1-(2-fluorodethyl)-acid crystal |
| abstract |
Disclosed is a technique for improving the water solubility and storage stability of 7-{(3S,4S)-3-[(cyclopropylamino)methyl]-4-fluoropyrrolidine-1-y1}-6-fluoro-1-(2-fluoroethyl)-8-methoxy-4-oxo-1,4-dihydroquinoline-3-carboxylic acid (compound (1)) that is safe and not only has a strong antibacterial action but also is effective for resistant bacteria for which conventional antibacterial agent are less effective. Crystals of the hydrochloride salt of the compound (1), crystals of the hydrochloride salt hydrate of the compound (1), and crystals of the methanesulfonate salt of the compound (1) are provided. In these crystals, decomposition due to influences of light is suppressed as compared to that in crystals of the compound (1) in free, and their storage stability is high. These crystals have higher solubility in water than the crystals of the compound (1) in free. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10154993-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2016074330-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9687453-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10918634-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9328089-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015284361-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-RE47785-E
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2019076421-A1 |
| priorityDate |
2011-11-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |