http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9085544-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a5930ed2292d797612e6caf1133d1e4b |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D303-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D301-19 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D303-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D301-19 |
| filingDate | 2013-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2015-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0838a9b2449380c2c2eb0bc747291ff4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e9946396fc018978ef959ce4b92fc2b7 |
| publicationDate | 2015-07-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-9085544-B2 |
| titleOfInvention | Method of synthesis of substituted hexitols such as dianhydrogalactitol |
| abstract | The present invention provides an efficient method of synthesizing and purifying dianhydrohexitols such as dianhydrogalactitol. In general, as applied to dianhydrogalactitol, the method comprises: (1) reacting dulcitol with a concentrated solution of hydrobromic acid at a temperature of about 80° C. to produce dibromogalactitol; (2) reacting the dibromogalactitol with potassium carbonate in t-butanol to produce dianhydrogalactitol; and (3) purifying the dianhydrogalactitol using a slurry of ethyl ether to produce purified dianhydrogalactitol. Another method produces dianhydrogalactitol from dulcitol; this method comprises: (1) reacting dulcitol with a reactant to convert the 1,6-hydroxy groups of dulcitol to an effective leaving group to generate an intermediate; and (2) reacting the intermediate with an inorganic weak base to produce dianhydrogalactitol through an intramolecular S N 2 reaction. Other methods for the synthesis of dianhydrogalactitol from dulcitol are described. |
| priorityDate | 2010-08-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 166.