| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fb3add8ddb1d098369e520dcd4e1205f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bc21395db315651889f9c4eb670a5f57
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7161d9ca6c752b56e66c50331097a099
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_806f0a3a49d26f0b2efb79a3ea184ce9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_896c9bf4940aa4083a5c83b9b3a21a25 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2760-16122
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2299-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B65D2501-0036 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B65D79-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B65D1-0223 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B65D1-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-483
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B65D79-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-08 |
| filingDate |
2008-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_261a09bc9b6b0fa5a43d2c6b8e3741b1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3832ce8935376c69b0c12ba26bb92160
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9684139baf290cd0f552b7df9ff1fbb4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c339adcafb98a7b4be14cac4cc883a5f |
| publicationDate |
2015-06-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9045248-B2 |
| titleOfInvention |
Soluble fragments of influenza virus PB2 protein capable of binding RNA-cap |
| abstract |
The present invention relates to soluble fragments of the Influenza virus RNA dependent RNA polymerase subunit PB2 and variants thereof, and crystallized complexes thereof comprising an RNA cap analog. This invention also relates to computational methods using the structural coordinates of said complex to screen for and design compounds that interact with the RNA cap binding pocket. In addition, this invention relates to methods identifying compounds that bind to PB2 polypeptide fragments comprising the RNA cap binding pocket, preferably inhibit the interaction with RNA caps or analogs thereof, by using said PB2 polypeptide fragments, preferably in a high-throughput setting. This invention also relates to compounds and pharmaceutical compositions comprising the identified compounds for the treatment of disease conditions due to viral infections caused by negative-sense single stranded RNA viruses. |
| priorityDate |
2007-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |