| abstract |
A cytosine analog, a method of preparation of a cytosine analog, a DNA methyltransferase 1 inhibitor, and a method for DNA methylation inhibition, is provided for the treatment of diseases associated with deviations from normal DNA methylation. The analog of cytosine may be comprised of 1, N 4 , 5 and 6-substituted derivatives of cytosine or 5,6-dihydrocytosine, wherein the analog can be described by the chemical formula n n n n n n n n n n nwhere R 1 is H, R 3 , R 4 , 2′-deoxyribosyl, R 4 is alkyl or aryl, X is N or C, wherein if X in the analog of formula I is N, then R 5 is no substituent and if X in the analog of formula I and/or II is C or if X in the analog of formula II is N, then R 5 and R 6 are independently alkyl, aryl, hydroxyalkyl, aminoalkyl, hydroxyl, carboxyl, amino group, alkoxyl, aryloxyl, aminoalkyl, aminoaryl, thio group, sulfonyl, sulfinyl or halogen. |