| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_00e28885047120a2cc4a61c2fe112448
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0ceaf7a4626761a2fa9ba5bf066bdf67
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c9c9bec18ba27b7ba42c0ec4fc3d34e2
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_afd43e12353298376fd7642260c1dbca
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_b893b9117040732dcc81ba976ebfdfe5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_aed6809d3187c5b72c8be4b64809d991
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dcce39a20bef16c3f04497659caba40f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_07c9542186133097bd6bbb7d92393090 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N25-4866 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 |
| classificationIPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N25-48 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01K17-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N25-14 |
| filingDate |
2009-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87b1406b5723209d4a9c73b0e26564de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_883b21bf28067ae98ca287739deca8c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e62c72fc1850ba752bb07da09b3cbd59
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ed6995eb56bb0b0f970458f3233d8fbb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d387203614a6b4afd67cb3306d7e3a7 |
| publicationDate |
2015-04-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-9004752-B2 |
| titleOfInvention |
Method for evaluating the solubility of a crystalline substance in a polymer |
| abstract |
A viable strategy to enhance the bioavailability of poorly soluble drugs is to use amorphous solids in place of the more commonly used crystalline solids in pharmaceutical formulations. However, amorphous solids are physically meta-stable and tend to revert back to their crystalline counterpart. An effective approach to stabilizing an amorphous drug against crystallization is to disperse it in a polymer matrix. The drug's solubility in the chosen polymer defines the upper limit of drug loading without any risk of crystallization. Measuring the solubility of a drug in a polymer has been a scientific and technological challenge because the high viscosity of polymers makes achieving solubility equilibrium difficult and because pharmaceutically important drug/polymer dispersions are glasses, which undergo structural relaxation over time. The invention provides a method based on Differential Scanning calorimetry (DSC) for measuring the solubility of crystalline drugs in polymeric matrices. The method relies on the detection of the dissolution endpoint of a drug/polymer mixture prepared by cryomilling. |
| priorityDate |
2008-05-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |