| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0f244c6155c2c1d73694b62b1c889927
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ca9c539f25d4c4dfac65460877f1e797
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f878432bdb5a3dfd8ccd9f6f839dfaa2 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2207-05 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-63 |
| filingDate |
2011-04-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28393c4a7124c52788c78ff8f79b11df
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a4dded1e23bdc262cc1dc92f67fd2d58 |
| publicationDate |
2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8993532-B2 |
| titleOfInvention |
Structurally designed shRNAs |
| abstract |
Provided is an improved design of shRNA based on structural mimics of miR-451 precursors. These miR-451 shRNA mimics are channeled through a novel small RNA biogenesis pathway, require AGO2 catalysis and are processed by Drosha but are independent of DICER processing. This miRNA pathway feeds active elements only into Ago2 because of its unique catalytic activity. These data demonstrate that this newly identified small RNA biogenesis pathway can be exploited in vivo to produce active molecules. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9624494-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10494647-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018187231-A3
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11090379-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10233464-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11007209-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11753641-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767183-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10888613-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10329562-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739350-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10975374-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10472649-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11519006-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10420789-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11583562-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10428350-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548914-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10772905-B2 |
| priorityDate |
2010-04-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |