| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_087bed7abab91ae0f927879f9fe8b273 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y02P20-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y106-02004
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0042 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P7-62
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P13-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-00 |
| filingDate |
2014-02-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d065ebd7acdfbdefb5485cbdc5fc1017
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f8e3650633ca731457adb7d29af039c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_936ab96f210d4c4f2c8857d1708c329c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_340002896963378f61a666415f400580
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0f7fd163420706d3b47b8963dffe91bc |
| publicationDate |
2015-03-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8993262-B2 |
| titleOfInvention |
In vivo and in vitro olefin cyclopropanation catalyzed by heme enzymes |
| abstract |
The present invention provides methods for catalyzing the conversion of an olefin to any compound containing one or more cyclopropane functional groups using heme enzymes. In certain aspects, the present invention provides a method for producing a cyclopropanation product comprising providing an olefinic substrate, a diazo reagent, and a heme enzyme; and admixing the components in a reaction for a time sufficient to produce a cyclopropanation product. In other aspects, the present invention provides heme enzymes including variants and fragments thereof that are capable of carrying out in vivo and in vitro olefin cyclopropanation reactions. Expression vectors and host cells expressing the heme enzymes are also provided by the present invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015232814-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11525123-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11008596-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10208322-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9493799-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9399762-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11518768-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018148745-A1 |
| priorityDate |
2012-10-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |