| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_244f416958677c8a082a81f213a5256e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cecb330a8df7f4a2dd25afd4b49ac88c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_7023181b563f2aa15082c248f214cf82
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_015c27707dd641eb59768a705b23690b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d5ab599c342b30dba7e07b4940b1bef5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_add7f848a92090ce51e3242544d97142 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 |
| filingDate |
2011-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9c2a18fb376f97dde6d703b1d64cd3cc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bf98fe70871df54caea51c15d94ba347
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1be894d08dc4b993d94ed10724e6f1fe
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5afb8c9c20bf9e27a6e7299abcfa2b17
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1193ccebef93b8924581adc374facb21 |
| publicationDate |
2015-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8981090-B2 |
| titleOfInvention |
Process for the synthesis of pemetrexed disodium salt |
| abstract |
The present invention relates to a novel process for the preparation of pemetrexed diethyl ester 2 n nby purifying the mixture obtainable by reacting compounds 1 and 1a in the presence of a chemical agent capable of promoting the formation of a peptide bond in an aprotic organic solventn n ncharacterized in that the mixture is subjected to the following steps:n a) washing with a basic aqueous solution; b) concentration of the organic phase; c) addition of a polar organic solvent and/or a mixture of polar organic solvents; d) precipitation of the pemetrexed diethyl ester 2. |
| priorityDate |
2010-07-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |