| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2dbd57cc234d32a39b689f83337902f
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c5fd35143ef51d0a109717564a4f7f53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_57f3e2af72b2933c004ed61dfccaaee1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b8dc689702f934bbd8b3d4b1b97be35
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e49e83a126f120db944c16c296e222ef |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57484
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57411
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2008-10-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b13c220b526a607064b81870512856e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0e3f6c9c2beec59cccae653d2ee5a5b5
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0dc3f43f4b950753b319a0a6e07ab7b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1d3fcc167a16aa4d0b081f616efb438f |
| publicationDate |
2015-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8975036-B2 |
| titleOfInvention |
Methods for improved diagnosis of dysplasias |
| abstract |
The present invention relates to a method for improved diagnosis of dysplasias based on simultaneous detection of INK4a gene products and at least one marker for cell proliferation. Particularly the present invention provides a method for discriminating dysplastic cells over-expressing INK4a gene products from cells over-expressing INK4a gene products without being dysplastic by detection of a marker suitable for characterizing the proliferation properties of the respective cell. The characterization of the proliferation properties may comprise the detection of a marker or a set of markers characteristic for active cell proliferation and/or a marker or a set of markers characteristic for retarded or ceased cell proliferation. The method presented herein thus enables for a specific diagnosis of dysplasias in histological and cytological specimens. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10246751-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10697966-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10822660-B2 |
| priorityDate |
2002-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |