| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51d028c578ae85cb937b5b34a5129fbc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01d63fa586bbcae554d9319ebc3560de
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_3d2a00f2932d2f26f9bc4c81b9cd6345
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_01dfac2cd07f2a5222250d75ce4ac269 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-301
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-9125
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-607
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2565-507 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6837
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6869
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N27-4145 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N27-414
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P19-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12M1-00 |
| filingDate |
2009-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c036cdae29166c95f57d31e4514a1b6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_93941bc21e6b77019a444d1f42c80195
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ff8c238f34d0ae8eb099d95fbdd4127 |
| publicationDate |
2015-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8962279-B2 |
| titleOfInvention |
Solid-phase chelators and electronic biosensors |
| abstract |
Methods for sequencing nucleic acids are presented. Sequencing is accomplished through the chemical amplification of the products of DNA synthesis and the detection of the chemically amplified products. In embodiments of the invention, a substrate is provided having a plurality of molecules of DNA to be sequenced attached and a plurality of molecules capable of chelating pyrophosphate ions attached, the DNA molecules to be sequenced are primed, and a next complementary nucleotide is incorporated and excised a plurality of times leading to the buildup of pyrophosphate ions locally around the DNA molecule to be sequenced. Pyrophosphate ions are captured by the substrate-attached chelators and electronically detected to determine the identity of the next complementary nucleic acid in the DNA molecule to be sequenced. Additionally, devices and methods are provided for detecting biomolecules through the detection of pyrophosphate ions. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9630175-B2 |
| priorityDate |
2009-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |