| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efbd211e8dd496ddf7abf25a01d301cb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_071c04093088a0236255cc9369ae6dd3 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5308 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-566
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-44
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-563
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2012-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_773825c0f3ad54b44c031d01c24db163 |
| publicationDate |
2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8951736-B2 |
| titleOfInvention |
Multimer glycosylated nucleic acid binding protein conjugates and uses thereof |
| abstract |
The technology relates in part to multimer conjugates comprising a scaffold linked to two or more polypeptides that specifically interact with a nucleic acid containing beta-D-glucosyl-hydroxymethylcytosine or beta-D-glucosyl-hydroxymethyluracil. The scaffold can be chosen from an antibody, an antibody fragment, a multimerized binding partner that interacts with a binding partner counterpart in each of the polypeptides, a polymer, and a polyfunctional molecule. The polypeptides can be from a kinetoplastid flagellate organism and may comprise a full-length native or modified protein or a fragment thereof that specifically interacts with the beta-D-glucosyl-hydroxymethylcytosine and/or the beta-D-glucosyl-hydroxymethyluracil in the nucleic acid. The conjugates provided herein can be used to detect the presence, absence or amount of beta-D-glucosyl-hydroxymethylcytosine and/or beta-D-glucosyl-hydroxymethyluracil-containing nucleic acid in a sample. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9739773-B1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11459573-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11608518-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10443091-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10465234-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10508301-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10533213-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10612076-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11072818-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10731204-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10563248-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10774373-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10767216-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793899-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11208683-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11078529-B2 |
| priorityDate |
2011-04-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |