| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_361d805adef0158a32b83c8f5ea28927
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcfa88b4285a09f454c4c31d911090ee
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f6b6b954b3480ee5a9e10b54a036d871
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6d5570a1e130a06ceff2cf50be82ba83
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_5bdc15214285a1bc5333f8854852aa43
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_66726ac503372544463d955474706c66 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-522
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-567 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-39591
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-28 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395 |
| filingDate |
2010-08-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8609e4b4bacb9ff0bfbbe9dd4d4fbf29
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ded8f9e27754c0da5622c8c8da634500
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da3af99133789a10894b53492aac12f0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e403cf75473acd1222fbfd32c7403c45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f06fc271b2b0ed07d02d3588b5d1cf58 |
| publicationDate |
2015-02-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8951516-B2 |
| titleOfInvention |
Variant immunoglobulins with improved manufacturability |
| abstract |
This invention relates to the modification of the amino acid sequence of an immunoglobulin molecule at certain key positions within regions of the VH and VL FR and CDR3 domains and/or the CH1 domain which are prone to aggregation. Immunoglobulins modified as described may display improved manufacturability, for example, reduced aggregation propensity and/or increased production levels. |
| priorityDate |
2009-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |