| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_026cc5487aac7079eb6b87b3db68e206
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a2d4a7131ba51022bcf7615be4d2af45
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_d4c5c421f2d5fa6ed1d35a79392267e0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41a639aa11b9b2f8063a3e6b8b22b557
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6e5bd81f81d70b75351330bd27ea00a1
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-6489
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12M47-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y304-24087
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N11-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-18 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-64
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N11-00 |
| filingDate |
2010-07-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d506fae5e3ef534fabea9334a53d5d01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_27bab3b5ba65330af3656824cbaacd24
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8104bec825fa9e0e95823cf591170429
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0ef5aa822f342d32323fbcf8d7920e8c |
| publicationDate |
2015-02-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8945895-B2 |
| titleOfInvention |
Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
| abstract |
Provided herein are methods for purifying recombinant A Disintegrin-like and Metallopeptidase with Thrombospondin Type 1 Motif 13 (ADAMTS13) protein from a sample. The method comprises enriching for ADAMTS13 protein by chromatographically contacting the sample with hydroxyapatite under conditions that allow ADAMTS13 protein to appear in the eluate or supernatant from the hydroxylapatite. The methods may further comprise tandem chromatography with a mixed mode cation exchange/hydrophobic interaction resin that binds ADAMTS13 protein. Additional optional steps involve ultrafiltration/diafiltration, anion exchange chromatography, cation exchange chromatography, and viral inactivation. Also provided herein are methods for inactivating virus contaminants in protein samples, where the protein is immobilized on a support. Also provided herein are compositions of ADAMTS13 prepared according to said methods. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11191818-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2023170553-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021024573-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018027169-A1 |
| priorityDate |
2009-07-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |