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grantDate 2015-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2015-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-8940916-B2
titleOfInvention Crystallization of (20R)-2-methylene-19-nor-24-difluoro-1α,25-dihydroxyvitamin D3
abstract Disclosed are methods of purifying the compound (20R)-2-methylene-19-nor-24-difluoro-1α,25-dihydroxyvitamin D 3 to obtain the compound in crystalline form. The methods typically include the steps of dissolving a product containing the compound in a solvent comprising hexane and 2-propanol, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of crystals, and recovering the crystals.
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