| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_bdc96bff90c27677161c60f18e2e441b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_efd09c296645384c4e1c770411f7aa01
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9f14e25dcb8ee665c1a0e1faa5b47534
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f7c5beb151f3c479e36f5b5f05a6d4b9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-156 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04 |
| filingDate |
2011-01-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2015-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_41e6ee5b8df6166cf93acb7317b3db2a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_90f596c05beddee4539acfe93bb5f525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b93c09fecddd58d8028b7db563b3809 |
| publicationDate |
2015-01-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8940486-B2 |
| titleOfInvention |
Oligonucleotides and methods for detecting KRAS and PIK3CA mutations |
| abstract |
Provided are oligonucleotides that are capable of detecting KRAS and PIK3CA mutations in both cancer patients and healthy individuals with high specificity in kPCR assays. When the oligonucleotides are used as forward primers in conjunction with a defined genotyping algorithm spreadsheet, the primers are capable of enhancing detection of KRAS codon 12, 13, and 61 and PIK3CA codon 542, 545, and 1047 single nucleotide polymorphisms (SNPs) in a background of wild-type sequences. The oligonucleotides of the present invention are also capable of preventing pseudogene amplification when the oligonucleotides are hybridized as reverse primers or detection probes to the mismatch sequences. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018124538-A1 |
| priorityDate |
2010-01-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |