| abstract |
The present invention relates to a compound represented by general formula I: n n n n n n n n n n n n or a stereoisomer, tautomer, hydrate, solvate or pharmaceutically acceptable salt thereof, wherein A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , R 2 , R 7 , W, X, Y and Z are defined within. These compounds are useful for the modulation of β-secretase enzyme activity and for the treatment of β-secretase mediated diseases, including Alzheimer's disease (AD) and related conditions. |