| abstract |
Disclosed is a process for producing an aminoadamantane carbamate derivative which is useful as a significant intermediate of an 11βHSD-1 inhibitor. n A process for producing an acid addition salt of a compound represented by the Formula (II): n nor a solvate of the acid addition salt, wherein R 1 and R 2 are each independently hydrogen, substituted or unsubstituted alkyl or the like; R 3 and R 4 are each independently hydrogen, substituted or unsubstituted alkyl or the like; and R 5 and R 6 are each independently hydrogen, halogen, carboxy, nitro, substituted or unsubstituted alkyl or the like;n which comprises separating an acid addition salt of a compound represented by the Formula (II) or a solvate of the acid addition salt by adding an acid to a mixture of syn isomer and anti isomer of a compound represented by the Formula (I): nn n n n n n n n n n n n wherein R 1 , R 2 , R 3 , R 4 , R 5 , and R 6 are as defined above, in the presence of a solvent. |