Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_068b124e9ed016a23e41cb66bb1ea42e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e3ddaec25917ae7e1e89843716dd7065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e6bf1f23808c8c6578e0cedcd1224034 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f9612b37ec7dc28f92e94a1b6118afce http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_a6c59a278d351dcf8b98afe8e3a63dfd http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ad8b88b42c4839f4f971619d8be520d3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_acf50236c4c141da66d99877359725e6 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07B2200-13 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-59 |
filingDate |
2012-09-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2014-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_79a71fbad627584dc960d489bed5eda5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d15099821c29ac9ab8b90a22e7b6378e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4916c9430f7d4f0f56a79404ecb35f12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_46087daf9f357514544f869fbb70b7e0 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ccce7979a8eb3b547abe2cf736db4ec9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbd88a56188f83fbb6fc1b1eec0c0de7 |
publicationDate |
2014-12-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-8901297-B2 |
titleOfInvention |
Compositions for modulating a kinase cascade and methods of use thereof |
abstract |
The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11497750-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10213435-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10196357-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10323001-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014213587-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10106505-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9556120-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9580387-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10973828-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021252008-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10617693-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2021198202-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9926273-B2 |
priorityDate |
2006-12-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |