http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8889364-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0755ea316348c8c322671fa495ddd42e http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f10ec45749ea9b78168a98bd19394909 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_58e052436943e5db3848bc33daba6551 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_10cb877f955b75034cbbd6c2910567fc |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7057 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-4728 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-775 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-085 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-924 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57438 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5767 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-576 |
| filingDate | 2010-05-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85bff39b3efe8dfce855764afd987637 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_319c846dd72687835359eb3d36aab8d1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_20af9e4b34699606fedd893591dd7593 |
| publicationDate | 2014-11-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8889364-B2 |
| titleOfInvention | Clinical diagnosis of hepatic fibrosis using a novel panel of low abundant human plasma protein biomarkers |
| abstract | The inventors have proposed a novel panel of human plasma protein biomarkers for diagnosing hepatic fibrosis and cirrhosis. Presently there is no reliable non-invasive way of assessing liver fibrosis. A 2D-PAGE based proteomics study was used to identify potential fibrosis biomarkers. Plasma from patients with hepatic cirrhosis induced by infection with the hepatitis C virus (HCV) were analyzed. Several proteins associated with liver scarring and potentially also related to viral infection were identified. These proteins include 14-3-3 protein zeta/delta, adiponectin, afamin, alpha-1-antitrypsin, alpha-2-HS-glycoprotein, apolipoprotein C-III, apolipoprotein E, C4b-binding protein beta chain, intact/cleaved complement C3dg, corticosteroid-binding globulin, fibrinogen gamma chain, beta haptoglobin at pH 5.46-5.49, haptoglobin-related protein, hemopexin, immunoglobulin J chain, leucine-rich alpha-2-glycoprotein, lipid transfer inhibitor protein, retinol-binding protein 4, serum paraoxonase/arylesterase 1, sex hormone-binding globulin and zinc-alpha-2-glycoprotein. These biomarkers can be used in conjunction with polypeptides in WO/2008/031051. The concentrations of these novel biomarkers can be determined using an immunoassay where the concentrations would reflect the extent of fibrosis. A fibrosis scoring scale for each of the novel biomarkers is proposed. The additive result from the scores of all the novel biomarkers would give a more reliable indication of the degree of fibrosis rather than examining individual biomarkers. |
| priorityDate | 2009-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 696.