http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8871460-B2
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8e5bc512c4e6521ef323aef9ae2a8bed http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_51b2ed6d3fb873c60c3b5f11f97c6f15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_decaa5346e7434b487da44ed9b9653df http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d22ce3aecedcc9ea889c4f87d02d9c3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1102d97620a4aa4d9f94940eb4f38d93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e033ba626a078a171ba7a692b2b9f1f5 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6896 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-37 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 |
| filingDate | 2010-11-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e5105cb3392d840e6eca7e5dda476333 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8be2b5d30d41da43f2b3483f3564ced5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_edb64790c9cf1c256d8ad6eefb910f29 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c20334049ca765fbd96c3e26d6ae4d45 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dcc9ebe1dc83d2855c8e1a5d2d06c66d |
| publicationDate | 2014-10-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-8871460-B2 |
| titleOfInvention | Gamma-secretase modulatory compounds, methods for identifying same, and uses therefor |
| abstract | In accordance with the present invention, it has been discovered that compounds which modulate the γ-secretase enzyme to make more of the shorter, less toxic and less aggregation-prone Aβ peptides (such as Aβ37 and Aβ38), while making less of the longer and more toxic and aggregation-prone AB peptides (such as AB40 and AB42) are useful as gamma-secretase modulators. In addition, these GSM compounds have further been discovered to have the selective property of modulating the formation of various AB peptides, while not inhibiting the overall activity of the γ-secretase enzyme. Thus, such compounds do not impede other critical functions of the γ-secretase enzyme, such as generating fragments from Notch that appear to control gene expression and cell differentiation. Therefore, in accordance with the present invention, there are provided screening assays useful for determining whether test compounds have GSM activity; accordingly, invention assays facilitate the identification of new gamma-secretase modulators. Such screening assays can be performed in a variety of ways, e.g., by assessing whether test compounds: lower the level of Aβ42 peptide, increase the level of Aβ37 and/or Aβ38 peptides, have substantially no effect on the processing of other γ-secretase substrates, and/or interact with at least one component of the γ-secretase complex. Also provided in accordance with the present invention are compounds having gamma-secretase modulatory activity as identified by any of the methods described herein; methods for producing formulations useful for modulating gamma-secretase activity, as well as the resulting formulations; methods for modulating gamma-secretase activity employing compounds identified according to invention methods and/or invention formulations, and the like. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2018079747-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10570122-B2 |
| priorityDate | 2009-11-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 522.