| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_eff8ca62394578ec04b1cdc515dd6a5e |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06165
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0808
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-0823
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06052
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K1-1075
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-101 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-06
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-103
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-097
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-083
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-062
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K2-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-107
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K1-00 |
| filingDate |
2009-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_632bc6915c2e1c2d206d17f79cc88ab2 |
| publicationDate |
2014-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8859730-B2 |
| titleOfInvention |
Native chemical ligation at serine and threonine sites |
| abstract |
A chemoselective chemical ligation method is disclosed. The method joins two peptide segments efficiently to produce a larger peptide or protein, by generating a natural peptide bond (Xaa-Ser and Xaa-Thr) at the ligation site (Xaa represents any 5 amino acid). The method requires two steps (FIG. 1 ( a )): a) reacting the starting peptide(s) to form an acetal intermediate with an acetal group at the ligation site; b) converting said acetal intermediate to a desired peptide or protein with said natural peptide bond. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9593142-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10011631-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015232504-A1 |
| priorityDate |
2009-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |