| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_41a639aa11b9b2f8063a3e6b8b22b557
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_700ff9a01db2075489cb7ed87392dc28 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-60
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48215
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-755
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-775 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-775
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-755 |
| filingDate |
2012-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2014-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b5b798e282c98cb25caeb44c75ae04c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85e9213af33b0d03020d4e605aeed544
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e81de91d22b9efe065d3073c96eabb5f |
| publicationDate |
2014-09-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8835388-B2 |
| titleOfInvention |
Polymer von Willebrand factor-conjugates |
| abstract |
The present invention relates to a proteinaceous construct (also designated as polymer-VWF-conjugate) comprising plasmatic and/or recombinant von Willebrand factor (VWF), said VWF being bound to at least one physiologically acceptable polymer molecule, as well as to a complex between said proteinaceous construct and at least one factor VIII (FVIII) protein. The physiologically acceptable polymer molecule can be, for instance, polyethylene glycol (PEG) or polysialic acid (PSA). Further the present invention relates to methods for prolonging the in vivo-half-life of VWF or FVIII in the blood of a mammal having a bleeding disorder associated with functional defects of or deficiencies of at least one of FVIII or VWF. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10370430-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10421798-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9758776-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9376672-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11685771-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10548953-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10745680-B2 |
| priorityDate |
2004-12-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |